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Apolipoprotein O

From Wikipedia, the free encyclopedia
APOO
Identifiers
AliasesAPOO, FAM121B, MIC26, Mic23, My025, Apolipoprotein O, MICOS26
External IDsOMIM: 300753; MGI: 1915566; HomoloGene: 11475; GeneCards: APOO; OMA:APOO - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024122

NM_001199337
NM_001199338
NM_001199339
NM_026673

RefSeq (protein)

NP_077027

NP_001186266
NP_001186267
NP_001186268
NP_080949

Location (UCSC)Chr X: 23.83 – 23.91 MbChr X: 93.41 – 93.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ApoO
Identifiers
SymbolApoO
PfamPF09769
InterProIPR019166
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.[5]

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.[5]

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184831Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079508Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi:10.1074/jbc.M510861200. PMID 16956892.
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Further reading

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This article incorporates text from the public domain Pfam and InterPro: IPR019166